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Buspirone’s mechanism of action is not known and it differs from typical benzodiazepines in that it does not exhibit muscle-relaxing or anticonvulsant effects. As well, it lacks the prominent sedative effect related with other anxiolytic drugs.
Pre-clinical studies have showed that buspirone to have a high affinity for serotonin receptors. It has no significant relation for benzodiazepine receptors, but has moderate affinity for dopamine receptors in the brain. Some studies do suggest the medication may have indirect effects on other neurotransmitter systems.
BuSpar is indicated for the management of anxiety disorders or short-term relief of anxiety symptoms, but not for anxiety or tension related with the stress of everyday life.
The recommended initial dose is 15mg per day (5mg 3 times a day) and to reach optimal therapeutic response, the dosage may be increased 5mg per day every 2 or 3 days, as needed. The maximum daily dosage should not be more than 60mg. In clinical trials, divided dosages of 20 to 30mg/day were common practice.
Adverse effects are rarely dangerous or intense. Some tend to disappear with continued use, or become less frequent if the starting dose is low and gradually increased.
The most frequent side effects include confusion, vertigo, headache, agitation, nausea, nervousness, light-headedness. Less frequent symptoms include insomnia, depression, difficulty concentrating, drowsiness, intestinal disorders, paresthesia, tremors, coordination disorders, tinnitus, disturbed visus, fatigue, weakness, Angina pectoris, sore throat, tachycardias, palpitations, dry mouth, muscle and joint pain.
Other, rare symptoms may include hallucinations, allergic reactions, subdermal bleeding, extrapyramidal symptoms, tunnel vision, urine retention, alopecia, psychosis, ataxia, epileptic seizures, syncope, pruritus, and urine retention. However, the dyscognitive adverse effects of benzodiazepines are completely lacking.
Other adverse effects have been reported, but with no more frequency than those encountered in placebo. An abnormal side effect reported has been an increased sense of smell.